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Molecular characterisation of a cellular conveyor belt in Clytia medusae. Alpha rhythm collapse predicts iso-electric suppressions during anesthesia. Understanding the effect of competition during evolutionary radiations : an integrated model of phenotypic and species diversification. Dynamics of centriole amplification in centrosome-depleted brain multiciliated progenitors.

Competition for resources may reinforce the evolution of altruism in spatially structured populations. Assessing the causes of diversification slowdowns : temperature-dependent and diversity-dependent models receive equivalent support. How differing modes of non-genetic inheritance affect population viability in fluctuating environments.

Natural Viruses of Caenorhabditis Nematodes. Unravelling the genes forming the wing pattern supergene in the polymorphic butterfly Heliconius numata. MicroRNA gene regulation in extremely young and parallel adaptive radiations of crater lake cichlid fish. Linker histones are fine-scale chromatin architects modulating developmental decisions in Arabidopsis.

Optical control of protein activity and gene expression by photoactivation of caged cyclofen. Transposition favors the generation of large effect mutations that may facilitate rapid adaption. The relative importance of ecological drivers of arbuscular mycorrhizal fungal distribution varies with taxon phylogenetic resolution. GemC1 is a critical switch for neural stem cell generation in the postnatal brain. Characterizing symbiont inheritance during host-microbiota evolution : Application to the great apes gut microbiota.

Phaeodactylum tricornutum. Neural signatures of sleep in zebrafish. Optical control of neuronal ion channels and receptors. Meta-omics reveals genetic flexibility of diatom nitrogen transporters in response to environmental changes.

Where and what? Frugivory is associated with more efficient foraging in three semi-free ranging primate species. Poultry population dynamics and mortality risks in smallholder farms of the Mekong river delta region. EEG power spectral density under Propofol and its association with burst suppression, a marker of cerebral fragility.

Spatiotemporal structure of cell fate decisions in murine neural crest. Fast calcium transients in dendritic spines driven by extreme statistics. A model with many small shifts for estimating species-specific diversification rates. Accounting for ocean connectivity and hydroclimate in fish recruitment fluctuations within transboundary metapopulations. Author Correction : The new nanophysiology : regulation of ionic flow in neuronal subcompartments.

Publisher Correction : The new nanophysiology : regulation of ionic flow in neuronal subcompartments. Transient Confinement of Ca V 2. Detecting dynamic spatial correlation patterns with generalized wavelet coherence and non-stationary surrogate data. Tridimensional mapping of Phox2b expressing neurons in the brainstem of adult Macaca fascicularis and identification of the retrotrapezoid nucleus.

DNA metabarcoding-Need for robust experimental designs to draw sound ecological conclusions. One-locus-several-primers : A strategy to improve the taxonomic and haplotypic coverage in diet metabarcoding studies. Comparative genomics of 10 new Caenorhabditis species. Cranial and endocranial diversity in extant and fossil atelids Platyrrhini : Atelidae : A geometric morphometric study.

Asymmetric ephaptic inhibition between compartmentalized olfactory receptor neurons. Single-molecule characterization of extrinsic transcription termination by Sen1 helicase. Assessing reproducibility of matrix factorization methods in independent transcriptomes.

Mapping and characterization of G-quadruplexes in the genome of the social amoeba Dictyostelium discoideum. ALFA : annotation landscape for aligned reads. Motile ciliogenesis and the mitotic prism. Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments. Local adaptation, dispersal evolution, and the spatial eco-evolutionary dynamics of invasion.

Males as somatic investment in a parthenogenetic nematode. Principles of plastid reductive evolution illuminated by nonphotosynthetic chrysophytes. The golden death bacillus Chryseobacterium nematophagum is a novel matrix digesting pathogen of nematodes. Teleconnection between phytoplankton dynamics in north temperate lakes and global climatic oscillation by time-frequency analysis.

Lipid markers and related transcripts during excitotoxic neurodegeneration in kainate-treated mice. Comparison of stochastic and deterministic frameworks in dengue modelling. Exon junction complex components Y14 and Mago still play a role in budding yeast.

Hope4Genes : a Hopfield-like class prediction algorithm for transcriptomic data. On logical bifurcation diagrams. Identification of microRNA clusters cooperatively acting on epithelial to mesenchymal transition in triple negative breast cancer. Genome sequencing of strains of the most prevalent clonal group of O1:K1:H7 Escherichia coli that causes neonatal meningitis in France.

Identification and characterisation of hypomethylated DNA loci controlling quantitative resistance in Arabidopsis. Transcription-dependent regulation of replication dynamics modulates genome stability. Lacroix L Bioinformatics. An inter-dimer allosteric switch controls NMDA receptor activity. Quantitative resistance to clubroot infection mediated by transgenerational epigenetic variation in Arabidopsis. MethMotif : an integrative cell specific database of transcription factor binding motifs coupled with DNA methylation profiles.

Comparative characterization of putative chitin deacetylases from Phaeodactylum tricornutum and Thalassiosira pseudonana highlights the potential for distinct chitin-based metabolic processes in diatoms. Cross-exchange of B-vitamins underpins a mutualistic interaction between Ostreococcus tauri and Dinoroseobacter shibae.

Downregulation of mitochondrial alternative oxidase affects chloroplast function, redox status and stress response in a marine diatom. Dengue modeling in rural Cambodia : Statistical performance versus epidemiological relevance. Transmission dynamics of re-emerging rabies in domestic dogs of rural China. Macroscale fluorescence imaging against autofluorescence under ambient light. Naldi A Front Physiol. Reconstruction of directed neuronal networks in a microfluidic device with asymmetric microchannels.

Amphioxus functional genomics and the origins of vertebrate gene regulation. Microglial phenotypes in the human epileptic temporal lobe. Author Correction : Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity. Author Correction : Clade-specific diversification dynamics of marine diatoms since the Jurassic. Cerebellar learning using perturbations. Active intermixing of indirect and direct neurons builds the striatal mosaic.

DNA methylation and gene expression alterations in zebrafish early-life stages exposed to the antibacterial agent triclosan. Fast confocal fluorescence imaging in freely behaving mice. Slower environmental change hinders adaptation from standing genetic variation. Clade-specific diversification dynamics of marine diatoms since the Jurassic. Chromosome evolution at the origin of the ancestral vertebrate genome. Microglia and early brain development : An intimate journey.

Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity. Nonsense-mediated mRNA decay involves two distinct Upf1-bound complexes. Compartmental models for seasonal hyperendemic bacterial meningitis in the African meningitis belt.

Multiple factors behind early diversification of skull morphology in the continental radiation of New World monkeys. Single particle trajectories reveal active endoplasmic reticulum luminal flow. UPF1-like helicase grip on nucleic acids dictates processivity. Dual-layer transposon repression in heads of Drosophila melanogaster.

Optogenetic stimulation of complex spatio-temporal activity patterns by acousto-optic light steering probes cerebellar granular layer integrative properties. Developmental and cancer-associated plasticity of DNA replication preferentially targets GC-poor, lowly expressed and late-replicating regions. A mating-type mutagenesis screen identifies a zinc-finger protein required for specific DNA excision events in Paramecium. Isolation and differential transcriptome of vascular smooth muscle cells and mid-capillary pericytes from the rat brain.

Accounting for non-stationarity in epidemiology by embedding time-varying parameters in stochastic models. Lewitus E Front Neuroanat. The gut microbiome is associated with behavioural task in honey bees. Cooperation, cis-interactions, versatility and evolutionary plasticity of multiple cis-acting elements underlie krox20 hindbrain regulation.

Pristionchus nematodes occur frequently in diverse rotting vegetal substrates and are not exclusively necromenic, while Panagrellus redivivoides is found specifically in rotting fruits. Clade diversification dynamics and the biotic and abiotic controls of speciation and extinction rates. Single molecule kinetics uncover roles for E.

Low resolution scans can provide a sufficiently accurate, cost- and time-effective alternative to high resolution scans for 3D shape analyses. The mysterious origins of microglia. Gene s and individual feeding behavior : Exploring eco-evolutionary dynamics underlying left-right asymmetry in the scale-eating cichlid fish Perissodus microlepis. Exon Junction Complexes can have distinct functional flavours to regulate specific splicing events. Ubiquitous abundance distribution of non-dominant plankton across the global ocean.

In need of signalling pathway data. Ependymal cilia beating induces an actin network to protect centrioles against shear stress. Spatiotemporal variation of the association between climate dynamics and HFRS outbreaks in Eastern China during and its geographic determinants. Transcriptional control and exploitation of an immune-responsive family of plant retrotransposons.

The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation. Molecular and epigenetic regulations and functions of the LAFL transcriptional regulators that control seed development. Dissection of DNA double-strand-break repair using novel single-molecule forceps.

Endocytosis-mediated siderophore uptake as a strategy for Fe acquisition in diatoms. Transcription-Coupled Repair and Complex Biology. Homoeolog expression bias in allopolyploid oleaginous marine diatom Fistulifera solaris. RSAT : regulatory sequence analysis tools 20th anniversary. Mib1 prevents Notch Cis-inhibition to defer differentiation and preserve neuroepithelial integrity during neural delamination.

Triheteromeric NMDA receptors : from structure to synaptic physiology. Urbanization prolongs hantavirus epidemics in cities. Connexin 43 Controls the Astrocyte Immunoregulatory Phenotype. Integrative analysis of large scale transcriptome data draws a comprehensive landscape of Phaeodactylum tricornutum genome and evolutionary origin of diatoms. Asymmetric adhesion of rod-shaped bacteria controls microcolony morphogenesis. High-throughput fecundity measurements in Drosophila.

Chemical regulation of body feather microbiota in a wild bird. Nanoplanktonic diatoms are globally overlooked but play a role in spring blooms and carbon export. Optogenetic Tractography for anatomo-functional characterization of cortico-subcortical neural circuits in non-human primates. Handedness in gestural and manipulative actions in male hunter-gatherer Aka pygmies from Central African Republic.

Differential influences of allometry, phylogeny and environment on the rostral shape diversity of extinct South American notoungulates. Natural Infection of C. Contrasting impacts of competition on ecological and social trait evolution in songbirds. A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner.

A global ocean atlas of eukaryotic genes. Single-cell genomics of multiple uncultured stramenopiles reveals underestimated functional diversity across oceans. The epibiotic life of the cosmopolitan diatom Fragilariopsis doliolus on heterotrophic ciliates in the open ocean.

Hexim1, an RNA-controlled protein hub. Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming. Modelling interaction dynamics between two foliar pathogens in wheat : a multi-scale approach. Spatial patterns generated by simultaneous cooperation and exploitation favour the evolution of altruism.

Neobodonids are dominant kinetoplastids in the global ocean. FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells. Greater pollination generalization is not associated with reduced constraints on corolla shape in Antillean plants.

Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements. Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression. Transcriptome profiling of sorted endoreduplicated nuclei from tomato fruits : how the global shift in expression ascribed to DNA ploidy influences RNA-Seq data normalization and interpretation.

Krox20 defines a subpopulation of cardiac neural crest cells contributing to arterial valves and bicuspid aortic valve. ANISEED : extending the integrated ascidian database to the exploration and evolutionary comparison of genome-scale datasets. The "sacral parasympathetic" : ontogeny and anatomy of a myth. Genomicus : karyotype evolutionary trees and on-the-fly synteny computing.

Laser microdissection : A powerful tool for genomics at cell level. Tangential migration of corridor guidepost neurons contributes to anxiety circuits. Nerves, H 2 O 2 and Shh : Three players in the game of regeneration. Statistics of randomly cross-linked polymer models to interpret chromatin conformation capture data. Automatized image processing of bovine blastocysts produced in vitro for quantitative variable determination. Author Correction : Resonant out-of-phase fluorescence microscopy and remote imaging overcome spectral limitations.

Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity. Boundary cap cells in development and disease. Egr1 deficiency induces browning of inguinal subcutaneous white adipose tissue in mice. The mechanism of variability in transcription start site selection. Quantitative 3D-imaging for cell biology and ecology of environmental microbial eukaryotes.

Comparative epigenomics in the Brassicaceae reveals two evolutionarily conserved modes of PRC2-mediated gene regulation. The fitness cost of mis-splicing is the main determinant of alternative splicing patterns. On place and time : microglia in embryonic and perinatal brain development. Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest.

Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABA A receptors at inhibitory synapses. Thieffry D, Toussaint A Bioessays. Resonant out-of-phase fluorescence microscopy and remote imaging overcome spectral limitations. Calibrated mitotic oscillator drives motile ciliogenesis. Barbour B Biophys J. Evolution of gene expression after whole-genome duplication : New insights from the spotted gar genome.

DNA methylation dynamics during early plant life. Genome sequencing and transcriptome analysis of Trichoderma reesei QM strain reveals a distal chromosome translocation to be responsible for loss of vib1 expression and loss of cellulase induction. Differential cellular responses associated with oxidative stress and cell fate decision under nitrate and phosphate limitations in Thalassiosira pseudonana : Comparative proteomics.

Electrostatics of non-neutral biological microdomains. Alpha subunit-dependent glycine receptor clustering and regulation of synaptic receptor numbers. Endodermal germ-layer formation through active actin-driven migration triggered by N-cadherin. Two loci single particle trajectories analysis : constructing a first passage time statistics of local chromatin exploration.

Optical Control of Tumor Induction in the Zebrafish. Single molecule high-throughput footprinting of small and large DNA ligands. Climate warming reduces gut microbiota diversity in a vertebrate ectotherm. Multi-scale tracking reveals scale-dependent chromatin dynamics after DNA damage. Bensaude O Mol Cell. Viral to metazoan marine plankton nucleotide sequences from the Tara Oceans expedition. Krox20 hindbrain regulation incorporates multiple modes of cooperation between cis-acting elements.

Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries. An ecological and digital epidemiology analysis on the role of human behavior on the Chikungunya outbreak in Martinique. The evolution of diatoms and their biogeochemical functions.

Climate warming : a loss of variation in populations can accompany reproductive shifts. Genetic identification of a hindbrain nucleus essential for innate vocalization. Interannual cycles of Hantaan virus outbreaks at the human-animal interface in Central China are controlled by temperature and rainfall. Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla. High precision detection of conserved segments from synteny blocks.

Myosin 7 and its adaptors link cadherins to actin. Cerebellar re-encoding of self-generated head movements. Experimental Evolution with Caenorhabditis Nematodes. RSAT matrix-clustering : dynamic exploration and redundancy reduction of transcription factor binding motif collections. An integrated calcium imaging processing toolbox for the analysis of neuronal population dynamics. Logical modeling of lymphoid and myeloid cell specification and transdifferentiation. Smooth 2D manifold extraction from 3D image stack.

Epithelial cell behaviours during neurosensory organ formation. Kapsimali M Development. Unreeling the chromatin thread : a genomic perspective on organization around the periphery of the Arabidopsis nucleus. Optocontrol of glutamate receptor activity by single side-chain photoisomerization. Evolutionary forces affecting synonymous variations in plant genomes. Chimeric origins of ochrophytes and haptophytes revealed through an ancient plastid proteome. The Natural Biotic Environment of Caenorhabditis elegans.

The genealogical decomposition of a matrix population model with applications to the aggregation of stages. A mechanistic study of helicases with magnetic traps. Flow cytometry sorting of nuclei enables the first global characterization of Paramecium germline DNA and transposable elements. An aggregation-removal model for the formation and size determination of post-synaptic scaffold domains.

Study of gene expression alteration in male androgenetic alopecia : evidence of predominant molecular signalling pathways. The development and functions of multiciliated epithelia. Caenorhabditis elegans as a Model for Microbiome Research. Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface. Accelerated body size evolution during cold climatic periods in the Cenozoic. Aozan : an automated post-sequencing data-processing pipeline.

Clustering coefficient and periodic orbits in flow networks. Introduction to Focus Issue : Complex network perspectives on flow systems. On the evolutionary origins of equity. Activity patterns of serotonin neurons underlying cognitive flexibility. Epigenetic memory and cell fate reprogramming in plants. Modelling plankton ecosystems in the meta-omics era.

Are we ready? Understanding bias in DNA repair. Utilization of interferometric light microscopy for the rapid analysis of virus abundance in a river. Oxidation of F-actin controls the terminal steps of cytokinesis. Recent progress in diatom genomics and epigenomics. Direct conversion of root primordium into shoot meristem relies on timing of stem cell niche development. A noninvasive optical approach for assessing chloride extrusion activity of the K-Cl cotransporter KCC2 in neuronal cells.

The hypothalamic NPVF circuit modulates ventral raphe activity during nociception. Insights into the design and interpretation of iCLIP experiments. Evolutionary genomics of the cold-adapted diatom Fragilariopsis cylindrus. Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates. Proteomic analysis of the Rett syndrome experimental model mecp2 Q63X mutant zebrafish.

Early born neurons are abnormally positioned in the doublecortin knockout hippocampus. Whole-GUV patch-clamping. Physiology : Mechanosensor of lung inflation identified. Goridis C Nature. Heritable expansion of the genetic code in mouse and zebrafish. Strain-specific impact of the high-pathogenicity island on virulence in extra-intestinal pathogenic Escherichia coli. Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation.

Whole genome DNA methylation : beyond genes silencing. BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire. Physiological adjustments and transcriptome reprogramming are involved in the acclimation to salinity gradients in diatoms.

RNA- and protein-mediated control of Listeria monocytogenes virulence gene expression. Microglia control the glycinergic but not the GABAergic synapses via prostaglandin E2 in the spinal cord. History of research on C.

IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans. Structure in the variability of the basic reproductive number R 0 for Zika epidemics in the Pacific islands. Extreme Diversity of Diplonemid Eukaryotes in the Ocean. A radial map of multi-whisker correlation selectivity in the rat barrel cortex.

Splicing repression allows the gradual emergence of new Alu-exons in primate evolution. The sacral autonomic outflow is sympathetic. The effects of archipelago spatial structure on island diversity and endemism : predictions from a spatially-structured neutral model. Backtracked and paused transcription initiation intermediate of Escherichia coli RNA polymerase. Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses.

Wireless inertial measurement of head kinematics in freely-moving rats. Mechanisms and functional roles of glutamatergic synapse diversity in a cerebellar circuit. Single-molecule, antibody-free fluorescent visualisation of replication tracts along barcoded DNA molecules. Plant Transgenerational Epigenetics. Into the Andes : multiple independent colonizations drive montane diversity in the Neotropical clearwing butterflies Godyridina. Allosteric regulation in NMDA receptors revealed by the genetically encoded photo-cross-linkers.

Full-field interferometry for counting and differentiating aquatic biotic nanoparticles : from laboratory to Tara Oceans. A 2D virtual reality system for visual goal-driven navigation in zebrafish larvae. Ecogenomics and potential biogeochemical impacts of globally abundant ocean viruses. Hyrien O FRes. Early-life sexual segregation : ontogeny of isotopic niche differentiation in the Antarctic fur seal. Formal derivation of qualitative dynamical models from biochemical networks. Biased Allostery.

Logical model specification aided by model-checking techniques : application to the mammalian cell cycle regulation. Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity. Multiciliated Cells in Animals. Emerging concepts in chromatin-level regulation of plant cell differentiation : timing, counting, sensing and maintaining. Complex heterochrony underlies the evolution of Caenorhabditis elegans hermaphrodite sex allocation.

A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting. Deciphering and modifying LAFL transcriptional regulatory network in seed for improving yield and quality of storage compounds. Regulation of mitotic spindle orientation : an integrated view. Molecular signatures of neural connectivity in the olfactory cortex. Cyanobacterial ultrastructure in light of genomic sequence data. Surface water areas significantly impacted dengue outbreaks in Guangzhou, China.

Counting numbers of synaptic proteins : absolute quantification and single molecule imaging techniques. Caenorhabditis elegans responses to bacteria from its natural habitats. Anchor cell signaling and vulval precursor cell positioning establish a reproducible spatial context during C. Altered zinc sensitivity of NMDA receptors harboring clinically-relevant mutations. The Arabidopsis thaliana mobilome and its impact at the species level. Estimating planktonic diversity through spatial dominance patterns in a model ocean.

The native microbiome of the nematode Caenorhabditis elegans : gateway to a new host-microbiome model. Hydrogen peroxide H2O2 controls axon pathfinding during zebrafish development. Ostreococcus tauri is a new model green alga for studying iron metabolism in eukaryotic phytoplankton. Diversity in cell motility reveals the dynamic nature of the formation of zebrafish taste sensory organs. Detection and tracking of overlapping cell nuclei for large scale mitosis analyses.

Erratum to : Understanding Brassicaceae evolution through ancestral genome reconstruction. Identification and characterization of DNA sequences that prevent glucocorticoid receptor binding to nearby response elements. Cyanobacterial symbionts diverged in the late Cretaceous towards lineage-specific nitrogen fixation factories in single-celled phytoplankton. Neurodegeneration, Neurogenesis, and Oxidative Stress Deciphering DNA replication dynamics in eukaryotic cell populations in relation with their averaged chromatin conformations.

Centriole continuity : out with the new, in with the old. Time-invariant feed-forward inhibition of Purkinje cells in the cerebellar cortex in vivo. Pathogens trigger top-down climate forcing on ecosystem dynamics. Plankton networks driving carbon export in the oligotrophic ocean. Replication landscape of the human genome. Small fluorescence-activating and absorption-shifting tag for tunable protein imaging in vivo. Search for a small egg by spermatozoa in restricted geometries.

Prss56, a novel marker of adult neurogenesis in the mouse brain. Noncoding and coding transcriptome responses of a marine diatom to phosphate fluctuations. The exon junction complex as a node of post-transcriptional networks. Master regulators in primary skin fibroblast fate reprogramming in a human ex vivo model of chronic wounds.

A versatile Multisite Gateway-compatible promoter and transgenic line collection for cell type-specific functional genomics in Arabidopsis. Characterizing and Comparing Phylogenies from their Laplacian Spectrum. Contribution of postsynaptic T-type calcium channels to parallel fibre-Purkinje cell synaptic responses. Reverse transcriptase genes are highly abundant and transcriptionally active in marine plankton assemblages. Eco-evolutionary feedbacks between private and public goods : evidence from toxic algal blooms.

Siderophore production and the evolution of investment in a public good : An adaptive dynamics approach to kin selection. Kaplan , Springer. Quasi-planktonic behavior of foraging top marine predators. Impaired PRC2 activity promotes transcriptional instability and favors breast tumorigenesis.

The evolution of adhesiveness as a social adaptation. Why so many sperm cells? Self-assembly and plasticity of synaptic domains through a reaction-diffusion mechanism. The new nanophysiology : regulation of ionic flow in neuronal subcompartments. Workshop report : Caenorhabditis nematodes as model organisms to study trait variation and its evolution. Braendle C, Teotonio H Worm. How rods respond to single photons : Key adaptations of a G-protein cascade that enable vision at the physical limit of perception.

Synaptic dynamics and neuronal network connectivity are reflected in the distribution of times in Up states. Syncytial apoptosis signaling network induced by the HIV-1 envelope glycoprotein complex : an overview. Neuronal and microglial regulators of cortical wiring : usual and novel guideposts. Marine microbial biodiversity, bioinformatics and biotechnology M2B3 data reporting and service standards.

Multilayer and interconnected post-transcriptional and co-transcriptional control of plant NLRs. Robust network oscillations during mammalian respiratory rhythm generation driven by synaptic dynamics. A microfluidic device to study neuronal and motor responses to acute chemical stimuli in zebrafish.

Atlas of Cancer Signalling Network : a systems biology resource for integrative analysis of cancer data with Google Maps. Pervasive robustness in biological systems. Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites. Energetic coupling between plastids and mitochondria drives CO2 assimilation in diatoms. Route to genetically targeted optical electrophysiology : development and applications of voltage-sensitive fluorescent proteins.

Open science resources for the discovery and analysis of Tara Oceans data. Bursting reverberation as a multiscale neuronal network process driven by synaptic depression-facilitation. Ocean plankton. Determinants of community structure in the global plankton interactome. Eukaryotic plankton diversity in the sunlit ocean.

Patterns and ecological drivers of ocean viral communities. Environmental characteristics of Agulhas rings affect interocean plankton transport. Structure and function of the global ocean microbiome. Tara Oceans. Tara Oceans studies plankton at planetary scale.

Computational eco-systems biology in Tara Oceans : translating data into knowledge. A new approach to the generation time in matrix population models. An integrative analysis of post-translational histone modifications in the marine diatom Phaeodactylum tricornutum. Partner choice creates fairness in humans. A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity.

Light signaling controls nuclear architecture reorganization during seedling establishment. Neuronal morphology generates high-frequency firing resonance. Zeb family members and boundary cap cells underlie developmental plasticity of sensory nociceptive neurons.

Control of brain patterning by Engrailed paracrine transfer : a new function of the Pbx interaction domain. Out-of-focus background subtraction for fast structured illumination super-resolution microscopy of optically thick samples. Long-range evolutionary constraints reveal cis-regulatory interactions on the human X chromosome.

Inferring epigenetic dynamics from kin correlations. Genome-wide negative feedback drives transgenerational DNA methylation dynamics in Arabidopsis. Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory. Subrepellent doses of Slit1 promote Netrin-1 chemotactic responses in subsets of axons.

Functional characterization of the diatom cyclin-dependent kinase A2 as a mitotic regulator reveals plant-like properties in a non-green lineage. Origin and diversification of living cycads : a cautionary tale on the impact of the branching process prior in Bayesian molecular dating. Trophic groups and modules : two levels of group detection in food webs.

When everything is not everywhere but species evolve : an alternative method to model adaptive properties of marine ecosystems. Ependymal cell differentiation, from monociliated to multiciliated cells. The neuroglial potassium cycle during neurotransmission : role of Kir4. CaRuby-Nano : a novel high affinity calcium probe for dual color imaging. Effect of dopaminergic D1 receptors on plasticity is dependent of serotoninergic 5-HT1A receptors in L5-pyramidal neurons of the prefrontal cortex.

How environmental conditions impact mosquito ecology and Japanese encephalitis : an eco-epidemiological approach. Bistability in a metabolic network underpins the de novo evolution of colony switching in Pseudomonas fluorescens. Immune quiescence of the brain is set by astroglial connexin Properties and molecular identity of NMDA receptors at synaptic and non-synaptic inputs in cerebellar molecular layer interneurons.

The Susd2 protein regulates neurite growth and excitatory synaptic density in hippocampal cultures. ChIP-exo signal associated with DNA-binding motifs provides insight into the genomic binding of the glucocorticoid receptor and cooperating transcription factors. Phylogenies support out-of-equilibrium models of biodiversity. A subcortical inhibitory signal for behavioral arrest in the thalamus. The Sarcoglycan complex is expressed in the cerebrovascular system and is specifically regulated by astroglial Cx30 channels.

The shortest path is not the one you know : application of biological network resources in precision oncology research. Contingency in the evolutionary emergence of reciprocal cooperation. Epigenetic basis of morphological variation and phenotypic plasticity in Arabidopsis thaliana. Oil accumulation by the oleaginous diatom Fistulifera solaris as revealed by the genome and transcriptome. Cooperative development of logical modelling standards and tools with CoLoMoTo.

Editorial overview : neurosciences : targeting glutamatergic signaling in CNS diseases : new hopes? Peaks cloaked in the mist : the landscape of mammalian replication origins. Hyrien O J Cell Biol. A novel protein, ubiquitous in marine phytoplankton, concentrates iron at the cell surface and facilitates uptake. A genomic region encompassing a newly identified exon provides enhancing activity sufficient for normal myo7aa expression in zebrafish sensory hair cells.

PRC2 represses dedifferentiation of mature somatic cells in Arabidopsis. Genome expansion of Arabis alpina linked with retrotransposition and reduced symmetric DNA methylation. Stochastic dynamics of adaptive trait and neutral marker driven by eco-evolutionary feedbacks. Presence in Mediterranean hotspots and floral symmetry affect speciation and extinction rates in Proteaceae.

Evolution of equal division among unequal partners. Molecular dissection of segment formation in the developing hindbrain. Membrane glycerolipid remodeling triggered by nitrogen and phosphorus starvation in Phaeodactylum tricornutum. Allosteric modulators of NMDA receptors : multiple sites and mechanisms. GenomicusPlants : a web resource to study genome evolution in flowering plants. Genomicus update : KaryoView and MatrixView provide a genome-wide perspective to multispecies comparative genomics.

Synaptic receptor dynamics : from theoretical concepts to deep quantification and chemistry in cellulo. Kinetics of aggregation with a finite number of particles and application to viral capsid assembly. Post-transcriptional regulation in the nucleus and cytoplasm : study of mean time to threshold MTT and narrow escape problem. The 3D organization of chromatin explains evolutionary fragile genomic regions.

Anhydrobiosis and freezing-tolerance : adaptations that facilitate the establishment of Panagrolaimus nematodes in polar habitats. Fast spatial beam shaping by acousto-optic diffraction for 3D non-linear microscopy.

Characterization of the angular memory effect of scattered light in biological tissues. Evidence for sequential and increasing activation of replication origins along replication timing gradients in the human genome.

Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways. Bessereau JL Ann Pathol. Genome engineering by transgene-instructed gene conversion in C. Single myelin fiber imaging in living rodents without labeling by deep optical coherence microscopy. Lateral diffusion on tubular membranes : quantification of measurements bias. Physiological roles of microglia during development. Transcription factor search for a DNA promoter in a three-state model. Inhibiting eukaryotic transcription : Which compound to choose?

How to evaluate its activity? Bensaude O Transcription. Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C. Late emergence of the vibrissa direction selectivity map in the rat barrel cortex. Mitotic spindle orientation in asymmetric and symmetric cell divisions during animal development. Physiological and molecular evidence that environmental changes elicit morphological interconversion in the model diatom Phaeodactylum tricornutum.

Replication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts. Integrative epigenomic mapping defines four main chromatin states in Arabidopsis. Functional reconstitution of Haemonchus contortus acetylcholine receptors in Xenopus oocytes provides mechanistic insights into levamisole resistance. Brain refractive index measured in vivo with high-NA defocus-corrected full-field OCT and consequences for two-photon microscopy. Decoding algal genomes : tracing back the history of photosynthetic life on Earth.

Molecular basis of NMDA receptor functional diversity. Paoletti P Eur J Neurosci. Nitric oxide regulates astrocyte maturation in the hippocampus : involvement of NOS2. Dok4 is involved in Schwann cell myelination and axonal interaction in vitro. Barhl2 limits growth of the diencephalic primordium through Caspase3 inhibition of beta-catenin activation.

A single immunoglobulin-domain protein required for clustering acetylcholine receptors in C. Functional specialization of Piwi proteins in Paramecium tetraurelia from post-transcriptional gene silencing to genome remodelling.

Screening for genes that wire the cerebral cortex. Heat shock cognate protein 70 regulates gephyrin clustering. Diffusion laws in dendritic spines. Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4. Stochastic modeling of gene activation and applications to cell regulation. Evolution and metabolic significance of the urea cycle in photosynthetic diatoms. Mobility in geometrically confined membranes.

Formation and stability of synaptic receptor domains. Super-resolution dynamic imaging of dendritic spines using a low-affinity photoconvertible actin probe. Fgf signaling controls pharyngeal taste bud formation through miR and Delta-Notch activity. A holistic approach to marine eco-systems biology. Labeling neuronal membrane receptors with quantum dots. Stemming epigenetics in marine stramenopiles. Stage-specific biomass overcompensation by juveniles in response to increased adult mortality in a wild fish population.

From the stochasticity of molecular processes to the variability of synaptic transmission. Ultrastructural organization of presynaptic terminals. A lateral belt of cortical LGN and NuMA guides mitotic spindle movements and planar division in neuroepithelial cells. Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development. Replication-associated mutational asymmetry in the human genome.

Physiological and toxic effects of purine intermediate 5-aminoimidazolecarboxamide ribonucleotide AICAR in yeast. Ploidy influences cellular responses to gross chromosomal rearrangements in Saccharomyces cerevisiae. Boundary cap cells are peripheral nervous system stem cells that can be redirected into central nervous system lineages. The CRE1 carbon catabolite repressor of the fungus Trichoderma reesei : a master regulator of carbon assimilation.

Comparative genome sequence analysis underscores mycoparasitism as the ancestral life style of Trichoderma. Encounter dynamics of a small target by a polymer diffusing in a confined domain. Protocol : Chromatin immunoprecipitation ChIP methodology to investigate histone modifications in two model diatom species.

Measuring aberrations in the rat brain by coherence-gated wavefront sensing using a Linnik interferometer. Evolution in developmental phenotype space. Positive modulation of a Cys-loop acetylcholine receptor by an auxiliary transmembrane subunit. Diffusion barriers constrain receptors at synapses. Histone H2B monoubiquitination facilitates the rapid modulation of gene expression during Arabidopsis photomorphogenesis.

Astrocyte-neuron communication : functional consequences. Integration of H-2Z1, a somatosensory cortex-expressed transgene, interferes with the expression of the Satb1 and Tbc1d5 flanking genes and affects the differentiation of a subset of cortical interneurons.

Eoulsan : a cloud computing-based framework facilitating high throughput sequencing analyses. Phox2b expression in the taste centers of fish. Mixed inhibitory synaptic balance correlates with glutamatergic synaptic phenotype in cerebellar unipolar brush cells. Iron utilization in marine cyanobacteria and eukaryotic algae. Modeling the step of endosomal escape during cell infection by a nonenveloped virus. Brownian needle in dire straits : stochastic motion of a rod in very confined narrow domains.

Cthrc1 is a negative regulator of myelination in Schwann cells. Intra-nuclear mobility and target search mechanisms of transcription factors : a single-molecule perspective on gene expression. Robustness and flexibility in nematode vulva development. Chloroplast-mitochondria cross-talk in diatoms. Using default constraints of the spindle assembly checkpoint to estimate the associated chemical rates.

From genes to function : the C. Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission. Tetrode recordings in the cerebellar cortex. Evolution and functional diversification of fructose bisphosphate aldolase genes in photosynthetic marine diatoms. Do replication forks control late origin firing in Saccharomyces cerevisiae?

Detection and quantification through a lipid membrane using the molecularly controlled semiconductor resistor. Engrailed homeoprotein recruits the adenosine A1 receptor to potentiate ephrin A5 function in retinal growth cones. Evolution of host life-history traits in a spatially structured host-parasite system.

Single-molecule studies using magnetic traps. Magnetic trap construction. Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators. Synaptic neurotransmitter-gated receptors. Role of pleiotropy in the evolution of a cryptic developmental variation in Caenorhabditis elegans.

Evolution of susceptibility to ingested double-stranded RNAs in Caenorhabditis nematodes. Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity. Life histories have a history : effects of past and present conditions on adult somatic growth rates in wild Trinidadian guppies.

Wavelet analysis for single molecule localization microscopy. Establishment of myelinating Schwann cells and barrier integrity between central and peripheral nervous systems depend on Sox Phylogenetic reconstruction and shell evolution of the Diplommatinidae Gastropoda : Caenogastropoda. Adaptation of granule cell to Purkinje cell synapses to high-frequency transmission.

Tye7 regulates yeast Ty1 retrotransposon sense and antisense transcription in response to adenylic nucleotides stress. Predation-associated differences in sex linkage of wild guppy coloration. Single-molecule mechanical identification and sequencing. PSF shaping using adaptive optics for three-dimensional single-molecule super-resolution imaging and tracking. Perispeckles are major assembly sites for the exon junction core complex.

Long-term species, sexual and individual variations in foraging strategies of fur seals revealed by stable isotopes in whiskers. Who are we? Why do we exist? What makes meaning, identity, community and connection? This crisis impacts our communities our organisations think The Office , our wider society and even nations. What have we become? It touches every touch point in our lives and is having serious ramifications on how our societies are evolving. O Wilson wrote that we yearn to belong and to have a purpose bigger than ourselves.

Without that purpose we lack meaning, and context, custom and tradition wane — yet we are meaning making creatures. In reality, neither of these approaches will suffice. This new philosophy is something that I explore in No Straight Lines -the means by which we can transform.

How to survive the middle-class crisis. Gonzalez de Cellerigo was a lawyer and an economist living in Spain. He writes, the riches which should have brought wealth have brought poverty. Cellerigo understood that the flood of money coming into Spain, over the last 4 decades had caused the value of money to fall.

Tagged aston reinvestment trust , boots the chemists and unions , british business bank , david boyle , demise of the middle class , designing for humanity , dorset , economic systems thinking , economics as if it mattered , failure uk public services , fall of spanish economy , future house prices in britain , future local economies , Gonzalez de Cellerigo , Innovation , International Labour organisation , KKR the barbarians at the gate , Kohlberg Kravis Roberts , london rebuilding society , new values in new economy , nonlinear innovation , private equity capitalists in breach of the European Convention on Human Rights , rethinking uk economy , rise of the p2p society , school dinners and education , school for social entrepreneurs , shareable cities , systems thinking in economics , the reinvention of the middle class , tim crabtree , west dorset food and land trust , west dorset food links , what to do about british economy , why the middle class matters.

Reading an article recently about Eliot Perlman who wrote what is considered a masterwork called Seven Types of Ambiguity. How does one make sense of an ambiguous world. This question is important to ask when there is significant disruption, or change in our lives, in industry, and when we see catastrophic failure and cannot arrive at a true diagnostic.

Tagged 7 types of ambiguity , Alan Moore , craftsmanship continuous improvement , creating value demand , future leadership in a networked world , No Straight Lines , nonlinear innovation , organisations of the future , systems design , systems diagnostics , wasteful organisations. A phrase he articulated to mean what politics at its best and most basic should be about. Tagged future economy Scotland , future leadership , future society , George Harrison , Gerry Hassan , hacking the future , new political institutions , No Straight Lines , political innovation scotland , Politics , Poverty , restorative economy , Scotland , social innovation in scotland.

There is a view that the recovery of our economy in the UK is underway. This, however, is not entirely true, because true regeneration is investment-led, not consumer-driven. It is these innovators, through sheer entrepreneurial endeavour, that are largely building the future rather than trying to protect the past.

Yet the ratios for capital formation in this country are terrible; broadly-speaking the percentage of GDP that is invested each year. We may as well just be sitting on it like Smaug in The Hobbit. Tagged Business , China , contract law for sme's , crowdcube , crowdfunding the law , democratising the law , investing in legal services , law as a platform , law for smes , Lawbite , legal document checking , lexis nexis , Matthew Hancock , Matthew Hancock MP , nonlinear innovation , secure esigning legal documents , Small and medium enterprises , startup loans , the future of legal services , the future of the law , Venture capital , Wassily Kandinsky.

Here are 10 ways of taking a more humane and commons based approach to how we could live. Tagged A common sense approach to building , Affordable housing , Alan Moore , Alejandro Aravena , Borneo-Sporenburg Amsterdam , building and the commons economy , community housing innovation , Community land trust , diversity in design , Horsmonden , Ijburg , innovation in architecture , innovation in housing , Iquique , land economy , margaret thatcher , Newton Community Land Trust , No Straight Lines , open commons region , openness is resilience , renewable buildings , restorative economy , self build innovation , self organising communities , Stroud , the cost of land , the low carbon economy , the new economics of building , Torre David Caracas.

Last year I was working with an extraordinary group of people in Salzburg — where we had come together to explore the potential of systemic transformation. In one exercise we worked collaboratively on an idea that each individually intrigued us. Mine was education. After many rounds of questioning — we were asked to write from the heart, intuitively what we felt.

This is what I wrote. Tagged Alan Moore , creativity and orginal thinking , educating the reflective practitioner , educating the world , education and values , education frees the world , education innovation , embracing change in our learning landscape , finalnd pioneers in education , Henry Jenkins , learning and poverty , learning and religious education , learning poverty and fundamentalism , learning reimagined , methods and theories of education , mobile education , nonlinear innovation , participatory learning , sir ken robinson , systemic change in education , talent and education , teaching creatively , technology and learning , what is creativity?

As Russ Ackoff said a hole is spelt with a W. Therefore sensing the entire system is key. When reading Miranda Swayers piece on the computing company for kids — Kano. Essentially Kano is plug and play coding making computing and the creation of things via coding and computing accessible to all comers. Hydes observation also resonated, when Alex Klein one of the Kano founders tells a story from an experience from Zuccotti Park when as a journalist he was covering the Occupy Movement, he asked the Occupy-ers why, if they hated big business so much, they all used iPhones and Samsungs.

Robotics is on the cusp of reshaping our world — in every aspect of our lives, from the waiting rooms of our hospitals to our battlefields, disaster prone world and our everyday lives. For good and for bad. Teaching the Dismal Science after the Crisis. Of course it is much much harder than anyone realises to bring into the world a truly viable alternative economy to an existing dominant model. Opportunism trying to outflank those that seek a more ambitious goal.

Tagged Alan Moore , closed loop economics , crafting a new economy , david simon two americas , economic philosophy , economics of nature , economy of the commons , embracing a complex world , john fullerton the capital institute , lessons open commons region , natural capitalism , networked economic theory , new thinking in economic philosophy , new tools for a new economy , nonlinear innovation , open science commons , rise of foodbanks uk economy , systems thinking in economics , teaching the new economics , the carbon neutral economy , the dismal science , the open economy , the p2p economy , the Post-Crash Economics Society , the resilient economy , the shareable economy , what's the use of economics.

LEGO has always fascinated me, because of its journey from small to great to almost has been to a company designed for meeting the demands and challenges of a non-linear world. The Lego swap service enables kids to try out and play with lots of different sets. Crowdfunding changes the rules for investing: In many ways Crowdfunding has come about because the Venture Capital market for startups has failed. So it is not surprising that a wide variety of startups are now finding their initial capital from crowdfunding platforms.

Tagged Alan Moore , angel investing , best crowdfunding in UK , crowdcube , crowdfunding , crowdfunding manchester , crowdfunding nordics , crowdfunding scotland , crowdfunding UK , Equity crowdfunding for SMEs , evolution of venture funding , failure uk vc market , funding circle , future local economies , george osborne working until 70 , innovation through smes , JOBS ACT , Jumpstart Our Business Startups Act , Lawbite at google campus , Matthew Hancock MP , mosaic solar crowdfunding , National Crowdfunding Association , No Straight Lines , people powered innovation , Small and medium enterprises , startup britain , Startup company , syndicate room , uk crowdfunding association , United States , Venture capital.

Today has been a special day. One of our obsessions is to see chaos as uncontrollable, primordial, dangerous which we as a species must strive at all costs to eviscerate from our lives. We all ride flows of matter and energy — flows driven ultimately by the energy from the sun. Tagged a complex world demands non-linear thinking , Alan Moore , art of hosting scotland , chaos theory , designing people powered organisations , Energy , enterprising futures schumacher , High performance organizations , Lee Smolin , Logical consequence , Mathematics , No Straight Lines , nonlinear innovation , nonlinear world , Nova Scotia , open systems design , openness new model society , openness resilience , Organization , Philosophy , six steps to transformation , Smolin , the power of chaos , transformational design.

Openness is resilience, leadership with purpose: Whereas one can see what happens when people exist in an open culture, which is led by purpose rather than a kpi. Two very different stories spring to mind, [1] the organisational systems change that was delivered through a process of participatory leadership in Nova Scotia for public health, [2] in Japan with Toyota.

If you start to think about designing for whole systems with real human beings operating in those systems — I believe we see a very different organisational design emerge. Tagged Alan Moore , art of hosting scotland , designing for humanity , designing healthcare systems , designing high performance organizations , future healthcare , future manufactuing , higher performing organizations , innovation nova scotia healthcare , innovation people power , innovation systems thinking , No Straight Lines , nonlinear innovation , north staffordshire hospital system failure , Open innovation , Otto Scharmer , radical redesign business , the greatest asset of an organization , theory u , transforming peoples lives.

Rupert Sheldrake takes us on a journey to stand in a different place and look at science from a natural perspective rather than a mechanistic one. Whether we think about science, management, organisational design. Our machine age: Newtonian determinstic thinking has permeated all aspects of our daily living lives. Sheldrake represents a broader philosophical evolution of reappraising how we see our world, universe and cosmology.

Tagged A new science of life , Alan Moore , business transformation , connected dynamic organism , new design for life , new models of business , No Straight Lines , nonlinear design , nonlinear innovation , Philosophy of Science , science and dogma , science universal possession of humanity , the transformation management , theology of science. His quote that a system is a w hole, spelt with a W was fantastic — his insight that a system is not a sum of its parts but a sum if the interactions that take place — genius for its clarity.

He made the point that to understand this concept write a note with your writing hand, then cut it off and see what happens. He is known as the father of systems thinking. Edwards Deming , effectiveness vs efficiency , John Seddon , Lloyd Dobyns , No Straight Lines , nonlinear innovation , quality as effectiveness , quality of life , stafford beer , systems design , Systems thinking , the vanguard method , toyota way , true knowledge exists in a network , w edwards deming.

Companies with engaged workforces achieve higher earnings than organisations that fail to engage their employees. Engaged organisations have 3. Flute Office is a pioneering company that is producing an entire suite of products along with a ground breaking business model to change the way we think about what we sit on, what we work on, what perhaps we do other things on Do its all verb.

Tashi Mannox Tibetan Calligrapher, says, it is commitment that gives you freedom, which reminds me of the truth that, the committed craftsman is the engaged craftsman. And that craftsman is always curious and happy to share the work and their knowledge.

A couple of weeks ago I headed north to a place called Todmorden, or Tod for those in the know. This is the homeland, of a particular beast called Incredible Edible. Incredible Edible has a mission to inspire and educate the world about food, local food, local food systems, locally gown food, local food economies, and how to lead a more resilient life that is also more fun.

Rupert Sheldrake talking about how science, that great bastion of exploration, still has its mechanistic head on. Mechanistic science, top down, and hierarchical. Sheldrake argues science as an idea still wears the mindset that everything is machine like, fixed like Newtons concept of cosmology. That there is no mystery in this world, all can be ordered and measured, indeed his story about the variations in light speed are compelling, and the attempts to regulate its speed at a constant, when in fact it varies, as does gravity.

They also say that disruption never comes from the centre, it always comes from the edge, from places where thinking and doing differently has greater flexibility. Perhaps it will not be the power houses of the industrial order where real and meaningful change comes from but elsewhere. What makes work meaningful? Why do we go to work? Why should we work? For whom do we work? Is work about meaning and identity more than money? Should our work be meaningful?

What fulfills us and what gets us out of bed on a Monday morning? It does not matter whether you are a coder, or a metal fabricator like Nicholas DiChiara, work is something that in my mind has always been about purpose and passion. Tim talks about meeting change with dignity. In No Straight Lines the core philosophy is we can do better and we need to deschool ourselves from a linear and mechanistic way of thinking and doing.

Here is Tim expanding on his philosophy on systems change at a human scale. How can we create better, much better? Where we can create better functioning societies, that are regenerative, more resilient. How can we shape the future of a country to be better prepared for a more uncertain and perhaps more challenging world? Tagged A green deal for Scotland?

For the last few months I have been working with, and, advising a company called Lawbite. It is disruptive to the existing legal profession, but that is no bad thing. Lawbite is well overdue. The authors argue that things that are good for the planet are also good for business. Studies from the the Economist Intelligence Unit, Harvard, MIT Sloan, and others indicate that organizations that commit to goals of zero waste, zero harmful emissions, and zero use of nonrenewable resources clearly outperform their competition.

Tagged Adnams Brewery , Alan Moore , bio engineering , Business model innovation , design thinking , designing for the collective good , designing resilient food systems , Economist Intelligence Unit , environmental management , green business , green economy , green engineering , holistic design , Hunter Lovins , John Seddon , Kanban , Lean manufacturing , Manufacturing , natural capitalism , No Straight Lines , nonlinear innovation , organizational design , quality of life , radical redesign business , systems design , theory of constraints , Toyota , toyota global vision , toyota way , United States , value based systems.

It was Jamie Lerner the Mayor of Curitiba who when he took office and facing many challenges decided to galvanise his citizens into life to make Curitiba work. Lerner said the work they undertook should be fun, fast and above all non-expensive. The idea that we own, or have ownership over our civic spaces is very important.

Home, hearth, kith and kin are all about belonging and identity. So this is a small story about those things. Below is a beautiful simple film about the craft of making sake. Why did I think it to be relevant? His hand is guided by his eye, informed by his creative mind; his productivity the act of unique creation.

Indeed, the master craftsman is adept in using a values based philosophical framework, as well as tools and materials, to deliver useful things to the world. I want to inspire young people. And when a child is two or three and starts farming mushrooms on the coffee waste of mum, then that child will never ever accept that there is real hunger in the world.

The child will only believe that there is ignorance in the world. Why do people work hard, and take pride in what they do? A short film about the Almonte horsemen. The narration is very simple but eloquent, that talks philosophically about meaning, identity, nature, belonging, ethics, community and the joy that comes from being committed to ones craft.

It has been said that privacy is dead. Not so. Openness will kill it. Writes Jeff Jarvis, he goes on, Openness is the more powerful weapon. Openness is the principle that guides, for example, Guardian journalism. Openness is all that can restore trust in government and technology companies. That said its not just about the net, its about the future direction of our societies, what does an open society looks like? Since genetic information does not determine you, it does not in itself tell you anything really important.

Our sense of privacy is evolving; our pictures, out personal data our views of what needs to be kept private change. So why would our genetic data be different? John Naughton in his recent column for The Observer, wrote that in or thereabouts, a phrase that data was new the oil came into public consciousness.

At the time I was sitting on the board of a company specialising in large scale social data analytics in those days mobile networks were large scale social networks , And I liked to use the term raw data has no value but refined data is the black gold of the 21st Century. A great, short film about a man committed to his craft and how that shapes his life.

What can we learn from that? It was terribly sad to hear the news of the passing to Seamus Heaney, a craftsman if ever there was one. As not only was he a master craftsman of the English language he embodied the other important characteristics of granite like integrity, and a deep empathy of the world around him and the people in it.

A quest for truth is always core to the purpose of a poet, to seek that which others do not see and to express it in a way that we can all understand. Our nonlinear world is about connectedness, our connectedness to each other and in fact to a wider universe.

Something I explore in No Straight Lines. I am deeply interested in our humanity and the human spirit. I am interested in humanities capacity for a higher yearning, which inspires us to work towards a greater good. Our pioneering spirit today should be more about the quality of life, and better governance of this planet. When we see the world as a deeper system, we see the world differently as this moving film explains.

Lee Smolin describes our universe at an atomic level as curved, open, diverse and highly networked, Manuel Castells describes our society as evolving into a networked one which as significant cultural and political implications, Janine Benyus talks about nature as a highly networked open, diverse eco-system from which we as humans have much to learn revolutionising how we invent, compute, heal ourselves, harness energy, repair the environment, and feed the world.

Tagged Biomimicry: Innovation Inspired By Nature , designing for transformation , designing resilient food systems , firm of the future , holistic design , human centered design , Janine Benyus , knowledge , Lee Smolin , living systems , Manuel Castell , multi-disciplinary design , natural ecosystems , Network Society , networks and disruption of traditional organization , networks as power , Open system systems theory , open systems design , organizational design , power of networks , systems based design , systems vision of the world.

One of my interests is how and why we work, what motivates us, and how can a values based systems help us make meaningful work. Patrick Stevenson Keating created a handcrafted glass particle accelerator in what I would describe as an act of true craftsmanship. The piece consists of a series of organically-shaped hand-blown glass bulbs — each attached to a pump via a tube to create a vacuum.

When the button is pushed, a voltage of 45,V is applied across two electrodes. I am almost finished reading Lee Smolins book Time Reborn, which is as fascinating as it is challenging. This book is about time and cosmology. A little out of my remit in some ways but I find that at times reading at the far edges of ones knowledge can lead to some interesting insights.

In No Straight Lines I use Openness as a principle, arguing that it can lead to a number of outcomes which are far more beneficial than closed systems; from accelerated innovation, to new ways of organising and providing a more invigorating cultural context for organisations to exist in, even new business models. John Naughton raises an interesting point about the proposed installation of data monitoring smart meters in 26 millions homes and its security implications in his Observer column.

Anderson , Russia , Smart meter , smart metering , Wireless Data. Tagged Alan Moore , Alternative , bbc , better sleep , Brittany Wenger , brittnay wenger , design thinking , digital health apps , england rubgy elite performance , Eric Topol , Fong , future cancer , future healthcare , future medicine , Ginger.

I picked this up from the wonderful p2p Foundation wiki about open source manufacturing, interesting to me as principle 3 of No Straight Lines in Open and Openness — Openness is resilience. And what are networks good at? Well, if a decision can be kept local, the person who knows most about the thing is the person who is dealing with it every day, the local decision. Tagged Alan Moore , Business , co-creation , compexity , Corporation , crowdfund , crowdfunding , Debian , Decision making , Hacking , harvesting natural systems , kevin kelly , leadership , Linux , natural systems , No Straight Lines , participatory cultures , participatory tools , systemns design , Systems thinking , the biology of machines , ushahidi , values based organization , Wikipedia.

I am a big fan of David Boyles work, and this book is one I think is as relevant today as it was when he wrote it in In this book he writes about the determined rejection of the fake, the virtual, the spun and the mass-produced, in the search for authenticity. If we are looking for a pattern one can also point to Mosaic Banking on the sun, a community investing in sustainable energy. Collective crowdfunding is also part of a global movement to go around those institutions that people believe have failed them.

Embedded in such design is a philosophy of networked sociability, and trust. As none of this works without it. It points to an alternative model of funding local projects which also mitigates risk. Tagged Alan Moore , community production , crowdcube , crowdfund , design literacy , economy 2. TED banned this talk, I wonder what was so controversial?

Of particular interest to me was the idea of variations in light-speed and gravity the big G. Sheldrake goes onto talk about the big idea that the laws of nature at an atomic level are never set, are not constant as Newton proposed but are in a permanent state of evolution. Tagged Alan Moore , Alternative , cern , Collapse: How societies choose to fail or survive , elementary particles , general relativity , Gottfried Wilhelm Leibniz , Graham Hancock , Gravitation , laws of nature , Lee Smolin , light-speed , natures laws , networked identity , networks and disruption of traditional organization , Newton , No Straight Lines , open to new ideas , Phenomenology of Perception , Physics , quantum mechanics , Roberto Mangabeira Unger , rupert sheldrake , smlxl , Speed of light , Ted , the atlantic , The Network Society , the process of evolution , time reborn , variations in light speed.

Published in The Guardian Sustainable Business. Our institutions, organisations and economies were conceived, designed and built for a simpler more linear world. Overwhelmed by complexity, these have become disrupted and unsustainable.

Tagged , Alan Moore , Business , Business model innovation , business models , Design , designing for transformation , dynamic adaptive systems , Earth , Economic model , economic systems thinking , enterprise open innovation , firm of the future , Guardian , Math , No Straight Lines , Nonlinear system , Open innovation , Organization , participatory cultures , participatory tools , Systems thinking. Tagged Alan Moore , co-creation , co-design , collaborative design , Guardian , Henry Jenkins , Human , human centered design , human os , No Straight Lines , Nova Scotia , Open innovation , organisational design , p2p society , Participatory budgeting , participatory cultures , participatory tools , Patients Know Best , Straight Lines.

Sometimes, we need to feel something rather than analyse it. To feel time, to feel space and pace, the feel love and to reflect, to touch and go into nature and revel in the crafting of of something unique. Sometimes we need to be open to a new experience, to take its crooked path to a deeper meaning about who we are, and perhaps where we belong. Sometimes its good to feel humbled by nature and reflect on how we only exist within her nurture, as much as we might abuse it. Sometimes its good to feel the mystical as it as much a part of our non-linear world as our current obsession with technology.

We have not harnessed the cosmos. Recently I was participating a workshop that was exploring the question, where do big ideas come from? We were a group of 20 people and asked to bring with us 2 ideas each that we found intriguing, ideas that we were undecided about but wanted to explore. Then through an intense collaborative process over 2 days we explored those ideas, digging deeper into them, exploring their emergence, their context, their potential for good and also disruption.

We explored patterns, connections and looked systemically at these ideas. Who would have thought even in , that consumer politics and societal politics would revolve around data, who has it, who owns it and how it is used, combined with the legal frameworks that protect us as citizens.

There are legitimate concerns about who actually owns this information, and when our identities can be pieced together via data flows, privacy becomes a key battleground. And there will be a pressing and increasing need to respect the sovereignty of the individual whether that be in a commercial or civil context. Tagged Alan Moore , Apple , booz hamilton allen , center for digital democracy , cloud security , cyber-surveillance system , data , data security , Democracy , digital democracy , edward snowden , Facebook , gchq , Google , national security agency , No Straight Lines , smlxl.

Principle 5 of No Straight Lines is Craftsmanship. Here artist Miyoko Shida demonstrates the idea of what it means to be fully engaged in an act of creation. In No Straight Lines, technology plays an important role, it must do. Because to deny our umbilical relationship with technology is to deny ourselves.

But it always seems a struggle to get people to reconcile the important philosophical, anthropological and societal relationships to technology that we indeed have — where it comes from, what drives our longing on a large scale which consequently affects what we imagine, create and make. As the shape of our world evolves, we are also in political transformation, both in terms of the political relationship between the individual and commercial organisations and the large Politics of how we organise and run our societies.

What should government look like in a non-linear world? Are we creating and running the right systems in the right way? This where I think organisations need a more nuanced approach to Transformation — being able to describe a new destination, with if necessary new organisational capability.

What's next for banking? Yeo Valley Farms, a masterclass in business transformation The challenge: How do we remove the acute volatility and therefore risk of running a farm? What can we learn from Shaker design? NASA shows us our beautifully interconnected planet Our nonlinear world understands everything is interconnected to everything else.

Dickson Despommier innovating the vertical farm This is how Dickson sees our future panning out. How do you rule the void once the party's over? LEGO cultures of creativity The LEGO Foundation are creating and sharing ground-breaking research on the power of play and creativity in learning, to act as a critical resource for thought leaders, influencers, educators and parents all around the world.

The healthy society and preventative medicine In recent years, scientific and technological developments have contributed to major progress in the health of individuals and for societies at large. The future of learning from the LEGO Foundation Curiosity is part and parcel of the creative process, and creativity is a key component of non-linear thinking. Cradling the transformative economy As we evolve for a linear model of economy.

Waste to Waves a story from the circular economy This a story about how we can think differently about material waste, upcycling, ans the circular economy.

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Aveva un tumore al cervello, lo scorso aprile i medici le avevano dato sei mesi di vita. La stampa americana dice che prima di suicidarsi Maynard ha pubblicato questo messaggio su Facebook:. Ho tante persone attorno a me persino adesso, mentre scrivo… Addio mondo.

Diffondete energie positive. Fate del bene agli altri! Aveva detto di voler aspettare dopo il compleanno del marito, che era il 26 ottobre, raccontando che stava ogni giorno peggio, tra dolore e convulsioni. Il Brittany Maynard Fund , la fondazione intitolata a Maynard, ha diffuso un lungo necrologio , che alla fine dice:. Right when I was I was diagnosed my husband and I were actively trying for a family, which is heartbreaking for us both.

We all just realized that I am terminally ill and I'm dying and I would just prefer to die with less pain and less suffering. I feel lucky I have tremendous support so I've never felt alone. The reason to consider life and what's of value is to make sure you're not missing out. Seize the day. What's important to you? What do you care about? What matters? Pursue that, forget the rest.

I'm choosing to suffer less. To put myself and my family through less pain. The thoughts that go through your mind when you find out you have so little time is everything that you need to say to everyone that you love. There is a difference between a person who is dying and a person who is suicidal. I do not want to die. I am dying. To have control of my own mind When I look at both options I have to die, I feel this is far more humane.

Who has the right to tell me that I don't deserve this choice?

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